Tiny circles called ecDNA are critical in cancer development and drug resistance. An international team publishes landmark studies detailing new findings and potential therapies.

Fearful memories are known to recruit neurons in a specific region of the brain called the amygdala. When we experience something frightening, the amygdala signals to other brain regions involved in ...

But they found that, unlike chromosomes, ecDNA transcription — the process of copying DNA sequences into RNA instructions that are then used to make proteins — continues unabated during cell division.

the research team were able to confirm that a transcription factor called Pf2 binds to a specific DNA consensus sequence. By ...

To function, enhancers are interpreted by transcription factors, or proteins, that bind to DNA sequences and then signal to ...

has focused its research on the role of tumor-associated transcription factors (TFs), proteins that bind to specific DNA sequences and act as regulators, and the derived development of TF inhibitors.

This interaction relaxes FOXA1’s DNA-binding sequence specificity and changes genome organization. This proves that transcription factors can be drugged, which may lead to new medicines ...

Cells synthesise messenger RNA (mRNA) using instructions in DNA and then ‘read’ instructions from the mRNA to make functional ...

The process is made up of the transcription and translation of DNA sequences. Genome and mutations DNA replication is carefully controlled to preserve the genetic information. However, changes in ...

Finally, the researchers describe a way to exploit ecDNA’s high rate of replication and transcription: a conflict between DNA ...

Check if you have access via personal or institutional login The aim of phonetic transcription is to represent the sounds of speech on paper. This book surveys the history of attempts to represent ...