The current landscape of nucleic acid therapeutics - Nature
WEBMay 31, 2021 · Here, we review four platform technologies that have enabled the clinical translation of nucleic acid therapeutics: antisense oligonucleotides, ligand-modified small interfering RNA conjugates,...
The DNA Drug Revolution - Scientific American
WEBJan 1, 2020 · Fabricating new genes to replace badly working versions, or to “silence” them, has produced 14 approved DNA-related drugs. And the latest research indicates that such therapies can be even ...
The DNA drug revolution - Nature
WEBDec 4, 2019 · The DNA drug revolution. Physicians have long been unable to touch the biological code that drives disease. That is changing as researchers develop DNA-based drugs, genes that replace or...
Matching drugs to DNA is 'new era of medicine' - BBC
WEBThe field of matching drugs to your DNA is known as pharmacogenomics. It would have helped Jane Burns, from Liverpool, who lost two-thirds of her skin when she reacted badly to a new epilepsy...
Biology and Development of DNA-Targeted Drugs, Focusing on …
WEBJan 6, 2024 · DNA-targeted drugs are a class of pharmaceutical agents designed to interact with and modulate the activity of DNA molecules within cells. These drugs are developed to treat various medical conditions, including cancer, genetic disorders, and infectious diseases, by directly impacting DNA structure, replication, transcription, repair, or …
How Designer DNA Is Changing Medicine - Scientific American
WEBJul 17, 2021 · How Designer DNA Is Changing Medicine. A genomic revolution is poised to cure sickle cell and other genetic diseases. By Carolyn Barber. Normal and sickle-shaped red blood cells. Getty Images...
DNA Damaging Drugs - PMC - National Center for Biotechnology …
WEBDNA damaging drugs interfere with transcription and reduplication. Affected cells respond with cell cycle arrest or programmed cell death. DNA damaging drugs are mutagenic, teratogenic, and carcinogenic.
DNA as Therapeutics; an Update - PMC - National Center for ...
WEBNow, gene therapy routinely is evoked to encompass the use of deoxyribonucleic acid (DNA) as a drug to alleviate the symptoms of a disease, even if the therapeutic genes are not strictly ‘corrective’ (in the sense of restoring a …
DNA Nanotechnology-Enabled Drug Delivery Systems
WEBFeb 21, 2018 · Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nanomedicine.
DNA Nanotechnology-Enabled Drug Delivery Systems - PubMed
WEBMay 22, 2019 · As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity.
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